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The discovery of a digestion slowing hormone in the Gila monster's venom paved the way for Ozempic. When a Gila monster named Pebbles needed medicine in return, a pharmaceutical chemist pivoted to help In my latest blog, The Pros and Cons of GLP 1 Agonist Medications, I walk through what to consider before starting, or while using, medications such as Ozempic, Wegovy, or Mounjaro. These medications Kourtney Kardashian just launched her own take on Ozempic IUPHAR review Glucagon like peptide 1 (GLP 1) and substance use disorders: An emerging pharmacotherapeutic target ScienceDirect Understanding GLP 1s Express Scripts Pharmacy GLP 1 Weight Loss Treatment Henry
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.6 ★★★★★
Based on 598 reviews
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Product Reviews
★★★★★ 5
6-Month Update: Still a staple for sensitive, acne-prone skin
Size: 3.38 Fl Oz (Pack of 1), Size: 3.38 Fl Oz (Pack of 1)
I originally reviewed this ampoule when I first started using it, and now after about six months of consistent use (morning and night), I feel confident giving a more long-term update.
I have sensitive, acne-prone, combination skin, and this has remained one of the most reliable products in my routine. The texture is still one of my favorite things about it — very lightweight, absorbs quickly, and layers well under moisturizer and sunscreen without pilling.
Over time, I’ve noticed:
Less visible redness
More balanced oil production in my T-zone
Fewer irritation flare-ups when introducing new products
No clogged pores or breakouts from this formula
It doesn’t feel heavy or sticky, even in humid weather. I’ve continued repurchasing and even keep it on subscription because it consistently performs without causing sensitivity.
If you’re looking for a gentle, soothing centella product that works well for long-term barrier support, this has proven to be a dependable option in my experience.
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Reviewed in the United States on December 9, 2025
★★★★★ 5
Healed my barrier so fast
Size: 3.38 Fl Oz (Pack of 1)
I received this ampoule yesterday and I'm already leaving a 5 star review after 2 uses because it just worked so well. I bought it because I've recently incorporated the Timeless 20% Vitamin C into my routine and that + my tretinoin made my skin drier than I've ever felt it before, even gently swiping a cotton pad with micellar would sting on some parts of my face. As soon as this ampoule arrived I applied it to clean skin and layered squalane on top (my moisturizer was burning as well.) This product did not sting my face AT ALL. It instead felt immediately soothing and hydrating. When I woke up this morning almost all of my redness was gone, my skin didn't feel tight or irritated, and my skin tone looked so even and glowy. I never thought a product, especially such a simply formulated one, could heal my barrier so quickly but that's exactly what it did and I can already tell it's a repeat buy. If you have redness prone sensitive skin and/or you use several high strength actives, this ampoule is a must have and it might be the key for anyone struggling to tolerate high strength retinoids. I got the largest size bottle for $15 on sale and it's seriously one of the most affordable and effective skincare products I've ever had in my routine.
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Reviewed in the United States on May 30, 2026
★★★★★ 5
Safe, Lightweight, Hydrating – Perfect for sensitive, super oily, acne-prone skin
Size: 1.85 Fl Oz (Pack of 1), Size: 1.85 Fl Oz (Pack of 1)
I care most about the ingredients, and this Madagascar Centella Ampule is excellent — all the ingredients are safe, with no potential harm to your health, and it’s Yuka app approved with a 100/100 safety score. I feel confident using it on my sensitive, super oily, acne-prone skin.
It’s super lightweight, absorbs quickly, and is not sticky at all — after applying, you just feel comfortable hydration. Even after a few hours, my skin doesn’t get oily, unlike some other serums I’ve used. It helps calm my skin and restore the barrier, which is perfect for my skin type. Even when I have acne wounds, it doesn’t irritate or sting — it’s extremely gentle. For sensitive, super oily, acne-prone skin like mine, it works wonderfully.
Living in Utah, one of the driest states in the U.S., this serum keeps my skin hydrated even in very dry conditions, and a little goes a long way — 1–1.5 drops cover my face and neck. Using more can make my skin slightly oily, so just the right amount works perfectly. For someone with dry skin, results may differ, but for my skin type, it works beautifully.
It’s also super affordable, and I’m glad it’s available on Amazon, with occasional great deals at Costco. I appreciate that it’s accessible at this price because this serum helps my skin a lot — very gentle on my acne-prone, sensitive, super oily skin.
The serum is super easy to apply with the dropper, which keeps other things from getting into the bottle — it’s perfect for easy, hygienic application. Just note that the bottle is glass, so be careful — it may break if dropped.
I’ve only been using it for three weeks, but it’s already a staple. I currently use one bottle, and the other two are extra for long-term use, especially since I got them on a great deal. This is now my main hydration serum, and I’ll update after longer use if needed.
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Reviewed in the United States on January 19, 2026
★★★★★ 5
Very impressed
Size: 3.38 Fl Oz (Pack of 1)
Really impressed by this serum! Got this to soothe my skin after overdoing it with too many different “actives”, and it gently and quickly got rid of redness and flaking, restored my skin barrier, and left my skin so moisturized and supple that I didn’t even feel like I needed lotion or cream afterwards. And it’s a GENEROUSLY sized glass bottle, too! I will definitely be trying other products from this brand!
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Best skincare product ever
Size: 3.38 Fl Oz (Pack of 1)
This ampoule is THE BEST THING EVER. I’ve been in the skincare industry since 1996 and I’ve never used a product that works as well as this. I have sensitive oily skin and it has a lot of redness. After the first use the redness was completely gone and the hydration was noticeable. Do not pass on this stuff! Highly recommend it for anyone wanting immediate hydration. It’s thin and isn’t sticky or tacky. It feels like I don’t have anything on my face but the benefits are definitely noticeable.
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Reviewed in the United States on April 18, 2026
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